???? ??
??? NCG ?????? ??? ? ???? ???? ??? ? ?? ?? ???? ???? ??? ?? ? ???, ?? ?? ????(cell derived xenograft, CDX) ??, ?? ?? ????(patient derived xenograft, PDX) ??, ?? ?????(hematopoietic stem cell, HSC) ? ????????(peripheral blood mononuclear cell, PBMC)? ??? ?? ??? ??? ??? ???? ?????? ??? ??????. NCG ? Next-Gen NCG ???? ????? ?? NOD/ShiLtJGpt ????? Prkdc (Protein kinase, DNA activated, catalytic polypeptide) ???? Il2rg (interleukin-2 receptor subunit gamma) ???? ??? ?? ?? ???(knockout)?? ??? ????. ??? ?? ??? ??? ? ??? ??? NCG ???? ?? ??? ? ?? CDX? 100 ? ?? ???? ????.
IMMUNODEFICIENT MOUSE MODELS
????? ?? ???? ??? ??? ??:
??? NCG ? Next-Gen NCG ??? ?????? ?? ?????? ??? PBMC, HSC, ?? ??? ???? ??? ???? ? ???.
??? ???? NCG ???? ??? 90? ????, ?? ?? ???? ??? ???? ? 15? ? ???.
Next-Gen NCG ??? ? ??? NCG-X? ??? ??(irradiation) ??? ??? ????, ????? ?? ??? ? ???? ?? ???? ?????.
??? CDX ???? ??? ??? ??? ? ?? ?? ?? ??? ????? ??? ? ?? ??? ??????.