MOUSE MODELS

????? ???? ???? ?? Knockout All Project(KOAP)? ??? ???? ???? 23,000??? ??? ??? ?? ??? ??? ?? ???(KO) ? ??? ???(cKO) ???? ???? ?? ??? ???. ??? ???? ???? ?? ?? 6,000? ??? ??? ???? ???? ??? ? ??, KO/cKO ???? ??? ????? ??? ? ????. ???? ?? 11,500? ???? ????? ?????, ??, ????, ??, ????? ?? ? ??? ??? ?????? KO ??? ? cKO ??? ??? ???? ????. ????? ???? ??? ???? ??? ??? ???? ???? ???? ??? ?? ??? ???? ????.

GemPharmatech has developed numerous disease mouse models using various modeling technologies, including transgenic (Tg), knockout (KO) and knockin (KI). These models can be used for metabolic, tumor, immunological, neurological, and other disease-related research applications.

??(Germ-free, GF) ???? ?? ?? ???? ????? ??? ? ???? ???? ??? ?? ???? ?? ???? ?? ???????. GF ???? ?? SPF ????? ??? ??? ??? ??? ??? ??? ??? ????? GF ???? ???? ?? ????? ?? ?????.

Cre-lox ???? ??? ??? ??? ?? ?? ???? ??? ??? ???? ?? ?? ???? ???? ?????. ????? in vivo?? Cre? ?? ???? ????? ???? ????? ???? ??? Cre ???? 200? ??, Dre/DreER ???? 9? ?? ???????.

??? ?? ??? ??? ???, ?? ?? ??? ??? ???? ??? ???, ???, ???? ???, ??? ? ?? ?? ???? ??? ??? ?? ????. ???? ? ??? ??? ?? ??? ?? 26?? ??? ?? ?? ??? ??? ??????.

Wild mice, different from laboratory inbred mice, survive in natural habitats and must adapt to numerous environmental stressors, resulting in greater genetic diversity, including single nucleotide polymorphisms (SNPs), deletions, and duplication of genomic sequences. According to previous studies, wild mice have varying susceptibilities to infectious diseases and may better mimic humans for preclinical drug screening and adverse?effect assessment.