• Wild Mouse 750

    Wild Mouse 750 (B6-Chr1YP1, No. D000750) has been developed to facilitate the study of obesity, fatty liver and other metabolic diseases. It possesses the wild mouse chromosome 1 on the C57BL/6JGpt background. It exhibits metabolic sensitivity making it a better model for metabolic disease research.


    Key Features

    • Increased genetic diversity through the introduction of an entire chromosome from a wild mouse.

    • Clear genetic background (except Chr 1) and good reproductivity contributed by its parental C57BL/6JGpt genome

    • The genetic variations that contribute its metabolic phenotypes are naturally occurring, and located on chromosome 1.

    image.png

    After 8 weeks of age, the body weight of 750 mice increased gradually. At 26 weeks of age, 750 and C57BL/6JGpt mice exhibited distinct tissue adiposity. The 750 mice had significantly enlarged adipose tissue at all depots. Mesenteric (m), subcutaneous (s), epididymal (e), white adipose tissue (WAT), brown adipose tissue (BAT).

    image.png

    After 8 weeks of age, the cholesterol levels of 750 mice increased gradually, and at 9 weeks of age, leptin and insulin levels were significantly higher than those in C57BL/6JGpt control mice.

    The disease characteristics of Wild Mouse 750 show more similarities to the human disease process than standard inbred mice and have a wide range of applications.

    Obesity: This strain develops spontaneous obesity after 8 weeks of age, with significant increase in food intake and severe leptin resistance.

    Abnormal glucose metabolism: Wild Mouse 750 exhibits mild and persistent hyperglycemia, insulin resistance, and glucose intolerance.

    Abnormal lipid metabolism: Lipid levels (Chol, LDL-C, HDL-C) increase significantly  after 8 weeks of age and continue to increase after Western diet (WD) feeding.

    MASLD/MASH: Aged mice exhibit a distinct fatty liver phenotype. WD feeding accelerates the development of MASH, including steatosis, lobular inflammation, and moderate fibrosis, with clinical NAS score of 7 and above.


    Metabolic Diseases Analysis Platform

    Not only Wild Mouse 750 is an ideal model for metabolic research as described above, it can also be used in preclinical efficacy evaluation of products targeting weight loss, hypoglycemia, hyperlipidemia, and MASH.

    With our proprietary mouse models and experienced scientific team, GemPharmatech offers a one-stop solution for metabolic disease research, including phenotyping and drug efficacy evaluation services to analyze metabolic, behavioral, and hematological indicators.

    Services Available

    Metabolism
    		Neurobehaviroal
    		Cardiovascular
    		Blood and Immunology

    Body Composition

    Metabolic cage

    Physiological cage

    Glucose tolerance test

    Water maze

    Rotarod

    Open field

    Blood pressure

    Electrocardiogram

    Cardiac ultrasound

    FACS, ELISA

    CBC

    Blood biochemistry

    Bone density

    Fat content



    TALK WITH OUR EXPERTS

    GemPharmatechは、お客様のプライバシーを保護し、尊重することをお約束します。お客様の個人情報は、アカウントの治理およびお客様からご要望いただいた製品やサービスの提供に利用いたします。時折、当社の製品やサービスに関する情報や、お客様に興味があるかもしれない他のコンテンツについてご連絡差し上げたいと考えております。お客様にこの目的をご連絡し、ご同意いただける場合は、以下の要领でお客様にどのようにご連絡させていただけるかをお知らせください。

    ご希望のコンテンツを提供するために、お客様の個人データを生存および処理する须要があります。この目的でお客様の個人データを生存することにご同意いただける場合は、以下のチェックボックスをクリックしてください。

    同意をいつでも撤回する権利があります。購読解除の詳細情報、当社のプライバシーに関する実践、およびお客様のプライバシーを保護し尊重するための取り組みについての詳細については、当社のプライバシーポリシーをご覧ください。