• BKS-db

    Research Overview

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    Figure 1. Overview of the BKS-db model study. 8–12 weeks is experimental period, the mice were randomly divided into 5-8 groups (10-12 mice per group).  


    Data Validation

    1. Body Weight Curve

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    Figure 2. The body weight of BKS-db mice increased rapidly after 4-weeks-old. Data are presented as Mean?±?SEM, n=20.


    2. Blood Glucose Levels

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    Figure 3. Blood glucose of BKS-db mice increased significantly compared with the control group, and remained stable after 8-week-old. Data are presented as Mean?±?SEM, n=6.


    3. Insulin levels

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    Figure 4. The insulin level in BKS-db was higher than the control in 8-week-old. Statistical analysis by two-tailed unpaired t test, data are presented as Mean±SEM, n=6 for each group. ****, P<0.0001.


    4. Blood Lipid levels

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    Figure 5. The Chol, TG, HDL-C and LDL-C levels in BKS-db mice were higher than control after 8 weeks. Statistical analysis by two-tailed unpaired t test, data are presented as Mean±SEM, n=20. ****, P<0.0001.


    5. Liver Function

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    Figure 6. The serum ALT and AST in BKS-db mice were significantly higher than that in BKS mice for the 8-week-old. Statistical analysis by two-tailed unpaired t test, data are presented as Mean±SEM. *, P<0.05; ****, P<0.0001.


    6. Fatty Liver and Pancreatic Islet Cell Lesions

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    Figure 7. BKS-db mice showed significant hepatic steatosis and islet architecture changes in the pancreas after 12 weeks old.


    7. Early Stage of Diabetic Kidney Disease

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    Figure 8. The urinary mAlb level was significantly increased in BKS-db mice from 12 weeks old. Statistical analysis by two-tailed unpaired t test, data are presented as Mean±SD. *, P<0.05.


    Efficacy Data

    1. Effects of Drug on Blood Glucose in BKS-db Mice

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    Figure 9. Test drug treatment significantly reduced the blood glucose in BKS-db mice. Statistical analysis by two-tailed unpaired t test, data are presented as Mean±SEM. **, P<0.01; ***, P<0.00 .


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